A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes
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چکیده
منابع مشابه
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis
A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death-related genes to determine their requirement in the regulation of starvation-induced autophagy. We discovered that six cell death genes--death caspase-1 (Dcp-1), hid, Bruce, Buffy, de...
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Caspases, a family of cysteine proteases, cleave substrates and play significant roles in apoptosis, autophagy, and development. Recently, our group identified 72 genes that interact with Death Caspase-1 (DCP-1) proteins in Drosophila by genetic screening of 15,000 EP lines. However, the cellular functions and molecular mechanisms of the screened genes, such as their involvement in apoptosis an...
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Increasing evidence reveals that a subset of proteins participates in both the autophagy and apoptosis pathways, and this intersection is important in normal physiological contexts and in pathological settings. In this paper, we show that the Drosophila effector caspase, Drosophila caspase 1 (Dcp-1), localizes within mitochondria and regulates mitochondrial morphology and autophagic flux. Loss ...
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M any cellular stresses, including starvation, induce cells to up-regulate the process of auto-phagy, in which cytoplasmic content is engulfed into autophagosomes and delivered to lysosomes for degradation. Auto-phagy can promote cell homeostasis and survival by removing damaged proteins and organelles and recycling their breakdown products to enhance cell metabolism. On the other hand, autopha...
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ژورنال
عنوان ژورنال: BMC Cell Biology
سال: 2010
ISSN: 1471-2121
DOI: 10.1186/1471-2121-11-9